Publications & Abstracts — Keith D. Garlid, M.D., PhD Archive

Peer-Reviewed Catalog (121 entries): Comprehensive record of research articles, review papers, and book chapters. Reprints are linked where available.

2018Uncoupling proteins (UCPs) & obesity

Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling

Ježek P, Holendová B, Garlid KD, Jabůrek M.

Antioxid Redox Signal. 2018 Sep 1;29(7):667-714. doi: 10.1089/ars.2017.7225. Epub 2018 Mar 14. doi:10.1089/ars.2017.7225

2017Water state in mitochondria, IMAC, & bioenergetics

Equipping Physiologists with an Informatics Tool Chest: Toward an Integrated Mitochondrial Phenome

Garlid AO, Polson JS, Garlid KD, Hermjakob H, Ping P.

Handb Exp Pharmacol. 2017;240:377-401. doi: 10.1007/164_2016_93. doi:10.1007/164_2016_93

2013Mitochondrial potassium cycle & cardioprotection

Mitochondrial reactive oxygen species: which ROS signals cardioprotection?

Garlid AO, Jaburek M, Jacobs JP, Garlid KD.

Am J Physiol Heart Circ Physiol. 2013 Oct 1;305(7):H960-8. doi: 10.1152/ajpheart.00858.2012. Epub 2013 Aug 2. doi:10.1152/ajpheart.00858.2012

2012Mitochondrial potassium cycle & cardioprotection

Mitochondrial ROMK channel is a molecular component of mitoK(ATP)

Foster DB, Ho AS, Rucker J, Garlid AO, Chen L, Sidor A, Garlid KD, O'Rourke B.

Circ Res. 2012 Aug 3;111(4):446-54. doi: 10.1161/CIRCRESAHA.112.266445. Epub 2012 Jul 17. doi:10.1161/CIRCRESAHA.112.266445

2012General Mitochondrial Bioenergetics

The mitochondrial K(ATP) channel--fact or fiction?

Garlid KD, Halestrap AP.

J Mol Cell Cardiol. 2012 Mar;52(3):578-83. doi: 10.1016/j.yjmcc.2011.12.011. Epub 2012 Jan 2. doi:10.1016/j.yjmcc.2011.12.011

2010Uncoupling proteins (UCPs) & obesity

Channel character of uncoupling protein-mediated transport

Jezek P, Jabůrek M, Garlid KD.

FEBS Lett. 2010 May 17;584(10):2135-41. doi: 10.1016/j.febslet.2010.02.068. Epub 2010 Mar 3. doi:10.1016/j.febslet.2010.02.068

2010Mitochondrial potassium cycle & cardioprotection

Preconditioning by subinotropic doses of ouabain in the Langendorff perfused rabbit heart

Morgan EE, Li Z, Stebal C, Belliard A, Tennyson G, Salari B, Garlid KD, Pierre SV.

J Cardiovasc Pharmacol. 2010 Mar;55(3):234-9. doi: 10.1097/FJC.0b013e3181ce5e14. doi:10.1097/FJC.0b013e3181ce5e14

2009Mitochondrial potassium cycle & cardioprotection

MitoKATP activity in healthy and ischemic hearts

Costa AD, Garlid KD.

J Bioenerg Biomembr. 2009 Apr;41(2):123-6. doi: 10.1007/s10863-009-9213-y. doi:10.1007/s10863-009-9213-y

2009Mitochondrial potassium cycle & cardioprotection

Cardioprotective signaling to mitochondria

Garlid KD, Costa AD, Quinlan CL, Pierre SV, Dos Santos P.

J Mol Cell Cardiol. 2009 Jun;46(6):858-66. doi: 10.1016/j.yjmcc.2008.11.019. Epub 2008 Dec 11. doi:10.1016/j.yjmcc.2008.11.019

2008Mitochondrial potassium cycle & cardioprotection

Conditioning the heart induces formation of signalosomes that interact with mitochondria to open mitoKATP channels

Quinlan CL, Costa AD, Costa CL, Pierre SV, Dos Santos P, Garlid KD.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H953-H961. doi: 10.1152/ajpheart.00520.2008. Epub 2008 Jul 11. doi:10.1152/ajpheart.00520.2008

2008Mitochondrial potassium cycle & cardioprotection

Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT

Costa AD, Garlid KD.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H874-82. doi: 10.1152/ajpheart.01189.2007. Epub 2008 Jun 27. doi:10.1152/ajpheart.01189.2007

2008Water state in mitochondria, IMAC, & bioenergetics

Differential increase of mitochondrial matrix volume by sevoflurane in isolated cardiac mitochondria

Riess ML, Costa AD, Carlson R Jr, Garlid KD, Heinen A, Stowe DF.

Anesth Analg. 2008 Apr;106(4):1049-55, table of contents. doi: 10.1213/ane.0b013e318167875e. doi:10.1213/ane.0b013e318167875e

2008General Mitochondrial Bioenergetics

cGMP signalling in pre- and post-conditioning: the role of mitochondria

Costa AD, Pierre SV, Cohen MV, Downey JM, Garlid KD.

Cardiovasc Res. 2008 Jan 15;77(2):344-52. doi: 10.1093/cvr/cvm050. Epub 2007 Oct 25. doi:10.1093/cvr/cvm050

2007General Mitochondrial Bioenergetics

Interactions of K+ATP channel blockers with Na+/K+-ATPase

Liu L, Gable ME, Garlid KD, Askari A.

Mol Cell Biochem. 2007 Dec;306(1-2):231-7. doi: 10.1007/s11010-007-9574-7. Epub 2007 Aug 25. doi:10.1007/s11010-007-9574-7

2007Mitochondrial potassium cycle & cardioprotection

Sarcoplasmic ATP-sensitive potassium channel blocker HMR1098 protects the ischemic heart: implication of calcium, complex I, reactive oxygen species and mitochondrial ATP-sensitive potassium channel

Pasdois P, Beauvoit B, Costa AD, Vinassa B, Tariosse L, Bonoron-Adèle S, Garlid KD, Dos Santos P.

J Mol Cell Cardiol. 2007 Mar;42(3):631-42. doi: 10.1016/j.yjmcc.2006.12.014. Epub 2006 Dec 30. doi:10.1016/j.yjmcc.2006.12.014

2007Mitochondrial potassium cycle & cardioprotection

Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts

Pierre SV, Yang C, Yuan Z, Seminerio J, Mouas C, Garlid KD, Dos-Santos P, Xie Z.

Cardiovasc Res. 2007 Feb 1;73(3):488-96. doi: 10.1016/j.cardiores.2006.11.003. Epub 2006 Nov 6. doi:10.1016/j.cardiores.2006.11.003

2007Mitochondrial potassium cycle & cardioprotection

Ouabain protects rat hearts against ischemia-reperfusion injury via pathway involving src kinase, mitoKATP, and ROS

Pasdois P, Quinlan CL, Rissa A, Tariosse L, Vinassa B, Costa AD, Pierre SV, Dos Santos P, Garlid KD.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1470-8. doi: 10.1152/ajpheart.00877.2006. Epub 2006 Nov 10. doi:10.1152/ajpheart.00877.2006

2006

Inhibition of cardiac contractility by 5-hydroxydecanoate and tetraphenylphosphonium ion: a possible role of mitoKATP in the response to inotropic stress

K. D. Garlid, P. E. Puddu, P. Pasdois, A. D. T. Costa, B. Beauvoit, A. Criniti, L. Tariosse, P. Diolez and P. Dos Santos.

K. D. Garlid, P. E. Puddu, P. Pasdois, A. D. T. Costa, B. Beauvoit, A. Criniti, L. Tariosse, P. Diolez and P. Dos Santos. (2006) Inhibition of cardiac contractility by 5-hydroxydecanoate and tetraphenylphosphonium ion: a possible role of mitoKATP in the response to inotropic stress. Am J Physiol

2006General Mitochondrial Bioenergetics

Mitochondrial PKC epsilon and mitochondrial ATP-sensitive K+ channel copurify and coreconstitute to form a functioning signaling module in proteoliposomes

Jabůrek M, Costa AD, Burton JR, Costa CL, Garlid KD.

Circ Res. 2006 Oct 13;99(8):878-83. doi: 10.1161/01.RES.0000245106.80628.d3. Epub 2006 Sep 7. doi:10.1161/01.RES.0000245106.80628.d3

2006Mitochondrial potassium cycle & cardioprotection

Opening mitoKATP increases superoxide generation from complex I of the electron transport chain

Andrukhiv A, Costa AD, West IC, Garlid KD.

Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2067-74. doi: 10.1152/ajpheart.00272.2006. Epub 2006 Jun 23. doi:10.1152/ajpheart.00272.2006

2006General Mitochondrial Bioenergetics

The mechanism by which the mitochondrial ATP-sensitive K+ channel opening and H2O2 inhibit the mitochondrial permeability transition

Costa ADT, Jakob R, Costa CL, Andrukhiv K, West IC, Garlid KD.

J Biol Chem. 2006 Jul 28;281(30):20801-20808. doi: 10.1074/jbc.M600959200. Epub 2006 May 23. doi:10.1074/jbc.M600959200

2006Mitochondrial potassium cycle & cardioprotection

Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection

Sato T, Costa AD, Saito T, Ogura T, Ishida H, Garlid KD, Nakaya H.

J Pharmacol Exp Ther. 2006 Jan;316(1):182-8. doi: 10.1124/jpet.105.094029. Epub 2005 Sep 20. doi:10.1124/jpet.105.094029

2006General Mitochondrial Bioenergetics

The direct physiological effects of mitoK(ATP) opening on heart mitochondria

Costa AD, Quinlan CL, Andrukhiv A, West IC, Jabůrek M, Garlid KD.

Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H406-15. doi: 10.1152/ajpheart.00794.2005. Epub 2005 Sep 2. doi:10.1152/ajpheart.00794.2005

2005

The direct effects of mitoKATP opening on the bioenergetics and physiology of heart mitochondria

A. D. T. Costa, C. Quinlan, A. Andrukhiv, I. C. West and K. D. Garlid.

A. D. T. Costa, C. Quinlan, A. Andrukhiv, I. C. West and K. D. Garlid. (2005) The direct effects of mitoKATP opening on the bioenergetics and physiology of heart mitochondria. Am J Physiol H290, 406-15.

2005Mitochondrial potassium cycle & cardioprotection

Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria

Costa AD, Garlid KD, West IC, Lincoln TM, Downey JM, Cohen MV, Critz SD.

Circ Res. 2005 Aug 19;97(4):329-36. doi: 10.1161/01.RES.0000178451.08719.5b. Epub 2005 Jul 21. doi:10.1161/01.RES.0000178451.08719.5b

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2004

Chemiosmotic Theory

K. D. Garlid

K. D. Garlid (2004) Chemiosmotic Theory. In "Encylopedia Biol Chem" (E. Carafoli, ed.) Elsevier, Amsterdam.

2004Uncoupling proteins (UCPs) & obesity

Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2

Jaburek M, Miyamoto S, Di Mascio P, Garlid KD, Jezek P.

J Biol Chem. 2004 Dec 17;279(51):53097-102. doi: 10.1074/jbc.M405339200. Epub 2004 Oct 8. doi:10.1074/jbc.M405339200

2004Mitochondrial potassium cycle & cardioprotection

Functional distinctions between the mitochondrial ATP-dependent K+ channel (mitoKATP) and its inward rectifier subunit (mitoKIR)

Mironova GD, Negoda AE, Marinov BS, Paucek P, Costa AD, Grigoriev SM, Skarga YY, Garlid KD.

J Biol Chem. 2004 Jul 30;279(31):32562-8. doi: 10.1074/jbc.M401115200. Epub 2004 May 11. doi:10.1074/jbc.M401115200

2004General Mitochondrial Bioenergetics

Alterations of the bioenergetics systems of the cell in acute and chronic myocardial ischemia

Dos Santos P, Laclau MN, Boudina S, Garlid KD.

Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):157-66. doi: 10.1023/b:mcbi.0000009866.75225.e2. doi:10.1023/b:mcbi.0000009866.75225.e2

2003Mitochondrial potassium cycle & cardioprotection

Mitochondrial potassium transport: the K(+) cycle

Garlid KD, Paucek P.

Biochim Biophys Acta. 2003 Sep 30;1606(1-3):23-41. doi: 10.1016/s0005-2728(03)00108-7. doi:10.1016/s0005-2728(03)00108-7

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2003Mitochondrial potassium cycle & cardioprotection

Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K(+) channel in cardiac function and cardioprotection

Garlid KD, Dos Santos P, Xie ZJ, Costa AD, Paucek P.

Biochim Biophys Acta. 2003 Sep 30;1606(1-3):1-21. doi: 10.1016/s0005-2728(03)00109-9. doi:10.1016/s0005-2728(03)00109-9

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2003Mitochondrial potassium cycle & cardioprotection

P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts

Oldenburg O, Yang XM, Krieg T, Garlid KD, Cohen MV, Grover GJ, Downey JM.

J Mol Cell Cardiol. 2003 Sep;35(9):1035-42. doi: 10.1016/s0022-2828(03)00151-2. doi:10.1016/s0022-2828(03)00151-2

2003Uncoupling proteins (UCPs) & obesity

Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10

Jaburek M, Garlid KD.

J Biol Chem. 2003 Jul 11;278(28):25825-31. doi: 10.1074/jbc.M302126200. Epub 2003 May 6. doi:10.1074/jbc.M302126200

2003Mitochondrial potassium cycle & cardioprotection

Involvement of mitogen-activated protein kinases and reactive oxygen species in the inotropic action of ouabain on cardiac myocytes. A potential role for mitochondrial K(ATP) channels

Tian J, Liu J, Garlid KD, Shapiro JI, Xie Z.

Mol Cell Biochem. 2003 Jan;242(1-2):181-7.

2002

Mechanisms by which opening the mitochondrial ATP-sensitive potassium channel protects the ischemic heart

P. Dos Santos, A. J. Kowaltowski, M. N. Laclau, S. Seetharaman, P. Paucek, S. Boudina, J.-B. Thambo, L. Tariosse, and K. D. Garlid

P. Dos Santos, A. J. Kowaltowski, M. N. Laclau, S. Seetharaman, P. Paucek, S. Boudina, J.-B. Thambo, L. Tariosse, and K. D. Garlid (2002) Mechanisms by which opening the mitochondrial ATP-sensitive potassium channel protects the ischemic heart. Am. J. Physiol. Heart Circ. Physiol. 283, H284-95.

2002Mitochondrial potassium cycle & cardioprotection

Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells

Krenz M, Oldenburg O, Wimpee H, Cohen MV, Garlid KD, Critz SD, Downey JM, Benoit JN.

Basic Res Cardiol. 2002 Sep;97(5):365-73. doi: 10.1007/s003950200045. doi:10.1007/s003950200045

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2001Mitochondrial potassium cycle & cardioprotection

The mitochondrial potassium cycle

Garlid KD, Paucek P.

IUBMB Life. 2001 Sep-Nov;52(3-5):153-8. doi: 10.1080/15216540152845948. doi:10.1080/15216540152845948

2001Uncoupling proteins (UCPs) & obesity

Mechanism of uncoupling protein action

Garlid KD, Jaburek M, Jezek P.

Biochem Soc Trans. 2001 Nov;29(Pt 6):803-6. doi: 10.1042/0300-5127:0290803. doi:10.1042/0300-5127:0290803

2001Uncoupling proteins (UCPs) & obesity

Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling

Jabůrek M, Varecha M, Jezek P, Garlid KD.

J Biol Chem. 2001 Aug 24;276(34):31897-905. doi: 10.1074/jbc.M103507200. Epub 2001 Jul 23. doi:10.1074/jbc.M103507200

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2001Mitochondrial potassium cycle & cardioprotection

Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain

Bajgar R, Seetharaman S, Kowaltowski AJ, Garlid KD, Paucek P.

J Biol Chem. 2001 Sep 7;276(36):33369-74. doi: 10.1074/jbc.M103320200. Epub 2001 Jul 5. doi:10.1074/jbc.M103320200

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2001General Mitochondrial Bioenergetics

Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity

Grover GJ, D'Alonzo AJ, Garlid KD, Bajgar R, Lodge NJ, Sleph PG, Darbenzio RB, Hess TA, Smith MA, Paucek P, Atwal KS.

J Pharmacol Exp Ther. 2001 Jun;297(3):1184-92.

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2001Mitochondrial potassium cycle & cardioprotection

Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase

Laclau MN, Boudina S, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adèle S, Saks VA, Garlid KD, Dos Santos P.

J Mol Cell Cardiol. 2001 May;33(5):947-56. doi: 10.1006/jmcc.2001.1357. doi:10.1006/jmcc.2001.1357

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2001General Mitochondrial Bioenergetics

Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria

Kowaltowski AJ, Seetharaman S, Paucek P, Garlid KD.

Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H649-57. doi: 10.1152/ajpheart.2001.280.2.H649. doi:10.1152/ajpheart.2001.280.2.H649

2000

Opening mitochondrial KATP in the heartCwhat happens, and what does not happen

K. D. Garlid

K. D. Garlid (2000) Opening mitochondrial KATP in the heartCwhat happens, and what does not happen. Basic. Res. Cardiol. 95, 275-279.

2000

Bimakalim: a promising KATP channel activating agent

P. E. Puddu, K. D. Garlid, F. Monti, K. Iwashiro, S. Picard, A. A. Dawodu, A. Criniti, G. Ruvulo, and P. P. Campa

P. E. Puddu, K. D. Garlid, F. Monti, K. Iwashiro, S. Picard, A. A. Dawodu, A. Criniti, G. Ruvulo, and P. P. Campa (2000) Bimakalim: a promising KATP channel activating agent. Cardiovasc. Drug. Rev. 18, 25-46.

2000General Mitochondrial Bioenergetics

Opening mitochondrial K(ATP) in the heart--what happens, and what does not happen

Garlid KD.

Basic Res Cardiol. 2000 Aug;95(4):275-9. doi: 10.1007/s003950070046. doi:10.1007/s003950070046

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2000Uncoupling proteins (UCPs) & obesity

How do uncoupling proteins uncouple?

Garlid KD, Jabůrek M, Jezek P, Varecha M.

Biochim Biophys Acta. 2000 Aug 15;1459(2-3):383-9. doi: 10.1016/s0005-2728(00)00175-4. doi:10.1016/s0005-2728(00)00175-4

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2000Mitochondrial potassium cycle & cardioprotection

ATP-Sensitive potassium channels: a review of their cardioprotective pharmacology

Grover GJ, Garlid KD.

J Mol Cell Cardiol. 2000 Apr;32(4):677-95. doi: 10.1006/jmcc.2000.1111. doi:10.1006/jmcc.2000.1111

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2000Water state in mitochondria, IMAC, & bioenergetics

The state of water in biological systems

Garlid KD.

Int Rev Cytol. 2000;192:281-302. doi: 10.1016/s0074-7696(08)60530-6. doi:10.1016/s0074-7696(08)60530-6

1999

Adenosine-mediated cardiac preconditioning extends beyond opening of the mitochondrial KATP channel in human myocardium

B. J. Pomerantz, J. C. Cleveland, Jr., K. D. Garlid, A. Banerjee, and A. H. Harken

B. J. Pomerantz, J. C. Cleveland, Jr., K. D. Garlid, A. Banerjee, and A. H. Harken (1999) Adenosine-mediated cardiac preconditioning extends beyond opening of the mitochondrial KATP channel in human myocardium. Surg. Forum 50, 94-96.

1999Uncoupling proteins (UCPs) & obesity

Transport function and regulation of mitochondrial uncoupling proteins 2 and 3

Jabůrek M, Varecha M, Gimeno RE, Dembski M, Jezek P, Zhang M, Burn P, Tartaglia LA, Garlid KD.

J Biol Chem. 1999 Sep 10;274(37):26003-7. doi: 10.1074/jbc.274.37.26003. doi:10.1074/jbc.274.37.26003

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1999Uncoupling proteins (UCPs) & obesity

Existence of uncoupling protein-2 antigen in isolated mitochondria from various tissues

Jezek P, Zácková M, Reháková Z, Růzicka M, Borecký J, Skobisová E, Brucknerová J, Garlid KD, Gimeno RE, Tartaglia LA.

FEBS Lett. 1999 Jul 16;455(1-2):79-82. doi: 10.1016/s0014-5793(99)00853-4. doi:10.1016/s0014-5793(99)00853-4

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1998Uncoupling proteins (UCPs) & obesity

Mammalian mitochondrial uncoupling proteins

Jezek P, Garlid KD.

Int J Biochem Cell Biol. 1998 Nov;30(11):1163-8. doi: 10.1016/s1357-2725(98)00076-4. doi:10.1016/s1357-2725(98)00076-4

1998Uncoupling proteins (UCPs) & obesity

The mechanism of proton transport mediated by mitochondrial uncoupling proteins

Garlid KD, Jabůrek M, Jezek P.

FEBS Lett. 1998 Oct 30;438(1-2):10-4. doi: 10.1016/s0014-5793(98)01246-0. doi:10.1016/s0014-5793(98)01246-0

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1998Uncoupling proteins (UCPs) & obesity

Fatty acid cycling mechanism and mitochondrial uncoupling proteins

Jezek P, Engstová H, Zácková M, Vercesi AE, Costa AD, Arruda P, Garlid KD.

Biochim Biophys Acta. 1998 Jun 10;1365(1-2):319-27. doi: 10.1016/s0005-2728(98)00084-x. doi:10.1016/s0005-2728(98)00084-x

1998Mitochondrial potassium cycle & cardioprotection

State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate

Jabůrek M, Yarov-Yarovoy V, Paucek P, Garlid KD.

J Biol Chem. 1998 May 29;273(22):13578-82.

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1997

A structure-function study of fatty acid interaction with mitochondrial uncoupling protein

P. Jezek, M. Modriansky, and K. D. Garlid

P. Jezek, M. Modriansky, and K. D. Garlid (1997) A structure-function study of fatty acid interaction with mitochondrial uncoupling protein. FEBS Lett. 408, 166- 170.

1997Mitochondrial potassium cycle & cardioprotection

Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection

Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, Grover GJ.

Circ Res. 1997 Dec;81(6):1072-82. doi: 10.1161/01.res.81.6.1072. doi:10.1161/01.res.81.6.1072

1997Mitochondrial potassium cycle & cardioprotection

The nucleotide regulatory sites on the mitochondrial KATP channel face the cytosol

Yarov-Yarovoy V, Paucek P, Jabůrek M, Garlid KD.

Biochim Biophys Acta. 1997 Aug 22;1321(2):128-36. doi: 10.1016/s0005-2728(97)00051-0. doi:10.1016/s0005-2728(97)00051-0

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1997Uncoupling proteins (UCPs) & obesity

Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition

Modrianský M, Murdza-Inglis DL, Patel HV, Freeman KB, Garlid KD.

J Biol Chem. 1997 Oct 3;272(40):24759-62. doi: 10.1074/jbc.272.40.24759. doi:10.1074/jbc.272.40.24759

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1997Uncoupling proteins (UCPs) & obesity

A structure-activity study of fatty acid interaction with mitochondrial uncoupling protein

Jezek P, Modrianský M, Garlid KD.

FEBS Lett. 1997 May 19;408(2):166-70. doi: 10.1016/s0014-5793(97)00335-9. doi:10.1016/s0014-5793(97)00335-9

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1997Uncoupling proteins (UCPs) & obesity

Inactive fatty acids are unable to flip-flop across the lipid bilayer

Jezek P, Modrianský M, Garlid KD.

FEBS Lett. 1997 May 19;408(2):161-5. doi: 10.1016/s0014-5793(97)00334-7. doi:10.1016/s0014-5793(97)00334-7

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1996

Cation transport in mitochondria B the potassium cycle

K. D. Garlid

K. D. Garlid (1996) Cation transport in mitochondria B the potassium cycle. Biochim. Biophys. Acta 1275, 123-126.

1996Mitochondrial potassium cycle & cardioprotection

Inhibition of the mitochondrial KATP channel by long-chain acyl-CoA esters and activation by guanine nucleotides

Paucek P, Yarov-Yarovoy V, Sun X, Garlid KD.

J Biol Chem. 1996 Dec 13;271(50):32084-8. doi: 10.1074/jbc.271.50.32084. doi:10.1074/jbc.271.50.32084

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1996Mitochondrial potassium cycle & cardioprotection

Cation transport in mitochondria--the potassium cycle

Garlid KD.

Biochim Biophys Acta. 1996 Jul 18;1275(1-2):123-6. doi: 10.1016/0005-2728(96)00061-8. doi:10.1016/0005-2728(96)00061-8

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1996Uncoupling proteins (UCPs) & obesity

Photoactivated azido fatty acid irreversibly inhibits anion and proton transport through the mitochondrial uncoupling protein

Jezek P, Hanus J, Semrad C, Garlid KD.

J Biol Chem. 1996 Mar 15;271(11):6199-205. doi: 10.1074/jbc.271.11.6199. doi:10.1074/jbc.271.11.6199

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1996Mitochondrial potassium cycle & cardioprotection

The mitochondrial KATP channel as a receptor for potassium channel openers

Garlid KD, Paucek P, Yarov-Yarovoy V, Sun X, Schindler PA.

J Biol Chem. 1996 Apr 12;271(15):8796-9. doi: 10.1074/jbc.271.15.8796. doi:10.1074/jbc.271.15.8796

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1996Uncoupling proteins (UCPs) & obesity

On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein

Garlid KD, Orosz DE, Modrianský M, Vassanelli S, Jezek P.

J Biol Chem. 1996 Feb 2;271(5):2615-20. doi: 10.1074/jbc.271.5.2615. doi:10.1074/jbc.271.5.2615

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1995

Fatty acid binding to the mitochondrial uncoupling protein

P. Jezek, M. Bauer, P. D. Vogel, K. D. Garlid, and W. E. Trommer

P. Jezek, M. Bauer, P. D. Vogel, K. D. Garlid, and W. E. Trommer (1995) Fatty acid binding to the mitochondrial uncoupling protein. Bull. Magn. Reson. 17, 126- 129.

1995General Mitochondrial Bioenergetics

Mitochondrial cation transport systems

Garlid KD, Sun X, Paucek P, Woldegiorgis G.

Methods Enzymol. 1995;260:331-48. doi: 10.1016/0076-6879(95)60149-x. doi:10.1016/0076-6879(95)60149-x

1994General Mitochondrial Bioenergetics

AA1, a newly synthesized monovalent lipophilic cation, expresses potent in vivo antitumor activity

Sun X, Wong JR, Song K, Hu J, Garlid KD, Chen LB.

Cancer Res. 1994 Mar 15;54(6):1465-71.

1994Uncoupling proteins (UCPs) & obesity

A single mutation in uncoupling protein of rat brown adipose tissue mitochondria abolishes GDP sensitivity of H+ transport

Murdza-Inglis DL, Modriansky M, Patel HV, Woldegiorgis G, Freeman KB, Garlid KD.

J Biol Chem. 1994 Mar 11;269(10):7435-8.

1994General Mitochondrial Bioenergetics

Reconstitution and partial purification of cardiac sarcolemmal Na+/H+ (K+/H+) antiporter

Periyasamy SM, Paucek P, Garlid KD, Askari A.

Arch Biochem Biophys. 1994 Aug 15;313(1):184-8. doi: 10.1006/abbi.1994.1376. doi:10.1006/abbi.1994.1376

1994Uncoupling proteins (UCPs) & obesity

Transport of anions and protons by the mitochondrial uncoupling protein and its regulation by nucleotides and fatty acids. A new look at old hypotheses

Jezek P, Orosz DE, Modriansky M, Garlid KD.

J Biol Chem. 1994 Oct 21;269(42):26184-90.

1994General Mitochondrial Bioenergetics

Mitochondrial cation transport: a progress report

Garlid KD.

J Bioenerg Biomembr. 1994 Oct;26(5):537-42. doi: 10.1007/BF00762738. doi:10.1007/BF00762738

1993General Mitochondrial Bioenergetics

On the regulation of Na+/H+ and K+/H+ antiport in yeast mitochondria: evidence for the absence of an Na(+)-selective Na+/H+ antiporter

Welihinda AA, Trumbly RJ, Garlid KD, Beavis AD.

Biochim Biophys Acta. 1993 Oct 4;1144(3):367-73. doi: 10.1016/0005-2728(93)90122-v. doi:10.1016/0005-2728(93)90122-v

1993Water state in mitochondria, IMAC, & bioenergetics

A sensitive new fluorescence assay for measuring proton transport across liposomal membranes

Orosz DE, Garlid KD.

Anal Biochem. 1993 Apr;210(1):7-15. doi: 10.1006/abio.1993.1143. doi:10.1006/abio.1993.1143

1993General Mitochondrial Bioenergetics

On the regulation of K+ uniport in intact mitochondria by adenine nucleotides and nucleotide analogs

Beavis AD, Lu Y, Garlid KD.

J Biol Chem. 1993 Jan 15;268(2):997-1004.

1992General Mitochondrial Bioenergetics

Evidence that spermine, spermidine, and putrescine are transported electrophoretically in mitochondria by a specific polyamine uniporter

Toninello A, Dalla Via L, Siliprandi D, Garlid KD.

J Biol Chem. 1992 Sep 15;267(26):18393-7.

1992The mitochondrial calcium cycle & calcium signaling

Reconstitution, identification, purification, and immunological characterization of the 110-kDa Na+/Ca2+ antiporter from beef heart mitochondria

Li W, Shariat-Madar Z, Powers M, Sun X, Lane RD, Garlid KD.

J Biol Chem. 1992 Sep 5;267(25):17983-9.

1992General Mitochondrial Bioenergetics

Reconstitution and partial purification of the glibenclamide-sensitive, ATP-dependent K+ channel from rat liver and beef heart mitochondria

Paucek P, Mironova G, Mahdi F, Beavis AD, Woldegiorgis G, Garlid KD.

J Biol Chem. 1992 Dec 25;267(36):26062-9.

1992Water state in mitochondria, IMAC, & bioenergetics

On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes

Sun X, Garlid KD.

J Biol Chem. 1992 Sep 25;267(27):19147-54.

1991Uncoupling proteins (UCPs) & obesity

Functional reconstitution of rat uncoupling protein following its high level expression in yeast

Murdza-Inglis DL, Patel HV, Freeman KB, Jezek P, Orosz DE, Garlid KD.

J Biol Chem. 1991 Jun 25;266(18):11871-5.

1991General Mitochondrial Bioenergetics

Reconstitution and partial purification of the Na(+)-selective Na+/H+ antiporter of beef heart mitochondria

Garlid KD, Shariat-Madar Z, Nath S, Jezek P.

J Biol Chem. 1991 Apr 5;266(10):6518-23.

1990General Mitochondrial Bioenergetics

Purification of a reconstitutively active K+/H+ antiporter from rat liver mitochondria

Li XQ, Hegazy MG, Mahdi F, Jezek P, Lane RD, Garlid KD.

J Biol Chem. 1990 Sep 5;265(25):15316-22.

1990Uncoupling proteins (UCPs) & obesity

New substrates and competitive inhibitors of the Cl- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria

Jezek P, Garlid KD.

J Biol Chem. 1990 Nov 5;265(31):19303-11.

1990Uncoupling proteins (UCPs) & obesity

Reconstitution of the uncoupling protein of brown adipose tissue mitochondria. Demonstration of GDP-sensitive halide anion uniport

Jezek P, Orosz DE, Garlid KD.

J Biol Chem. 1990 Nov 5;265(31):19296-302.

1990General Mitochondrial Bioenergetics

Reconstitution of the beef heart and rat liver mitochondrial K+/H+ (Na+/H+) antiporter. Quantitation of K+ transport with the novel fluorescent probe, PBFI

Jezek P, Mahdi F, Garlid KD.

J Biol Chem. 1990 Jun 25;265(18):10522-6.

1990General Mitochondrial Bioenergetics

Ion specificity of cardiac sarcolemmal Na+/H+ antiporter

Periyasamy SM, Kakar SS, Garlid KD, Askari A.

J Biol Chem. 1990 Apr 15;265(11):6035-41.

1990Water state in mitochondria, IMAC, & bioenergetics

Evidence for the allosteric regulation of the mitochondrial K+/H+ antiporter by matrix protons

Beavis AD, Garlid KD.

J Biol Chem. 1990 Feb 15;265(5):2538-45.

1990Uncoupling proteins (UCPs) & obesity

New insights into mechanisms of anion uniport through the uncoupling protein of brown adipose tissue mitochondria

Garlid KD.

Biochim Biophys Acta. 1990 Jul 25;1018(2-3):151-4. doi: 10.1016/0005-2728(90)90237-x. doi:10.1016/0005-2728(90)90237-x

1989General Mitochondrial Bioenergetics

On the nature of ion leaks in energy-transducing membranes

Garlid KD, Beavis AD, Ratkje SK.

Biochim Biophys Acta. 1989 Sep 28;976(2-3):109-20. doi: 10.1016/s0005-2728(89)80219-1. doi:10.1016/s0005-2728(89)80219-1

1989General Mitochondrial Bioenergetics

Reconstitution of the mitochondrial non-selective Na+/H+ (K+/H+) antiporter into proteoliposomes

Kakar SS, Mahdi F, Li XQ, Garlid KD.

J Biol Chem. 1989 Apr 5;264(10):5846-51.

1989General Mitochondrial Bioenergetics

Evidence for two distinct chloride uniport pathways in brown adipose tissue mitochondria

Jezek P, Beavis AD, Diresta DJ, Cousino RN, Garlid KD.

Am J Physiol. 1989 Dec;257(6 Pt 1):C1142-8. doi: 10.1152/ajpcell.1989.257.6.C1142. doi:10.1152/ajpcell.1989.257.6.C1142

1988General Mitochondrial Bioenergetics

On the mechanism of spermine transport in liver mitochondria

Toninello A, Miotto G, Siliprandi D, Siliprandi N, Garlid KD.

J Biol Chem. 1988 Dec 25;263(36):19407-11.

1988General Mitochondrial Bioenergetics

Sodium/proton antiporters in the mitochondrial inner membrane

Garlid KD.

Adv Exp Med Biol. 1988;232:37-46. doi: 10.1007/978-1-4757-0007-7_4. doi:10.1007/978-1-4757-0007-7_4

1988Water state in mitochondria, IMAC, & bioenergetics

Inhibition of the mitochondrial inner membrane anion channel by dicyclohexylcarbodiimide. Evidence for a specific transport pathway

Beavis AD, Garlid KD.

J Biol Chem. 1988 Jun 5;263(16):7574-80.

1987Water state in mitochondria, IMAC, & bioenergetics

The mitochondrial inner membrane anion channel. Regulation by divalent cations and protons

Beavis AD, Garlid KD.

J Biol Chem. 1987 Nov 5;262(31):15085-93.

1986General Mitochondrial Bioenergetics

On the mechanism by which dicyclohexylcarbodiimide and quinine inhibit K+ transport in rat liver mitochondria

Garlid KD, DiResta DJ, Beavis AD, Martin WH.

J Biol Chem. 1986 Feb 5;261(4):1529-35.

1986General Mitochondrial Bioenergetics

K+-H+ exchange and volume homeostasis in brown adipose tissue mitochondria

DiResta DJ, Kutschke KP, Hottois MD, Garlid KD.

Am J Physiol. 1986 Oct;251(4 Pt 2):R787-93. doi: 10.1152/ajpregu.1986.251.4.R787. doi:10.1152/ajpregu.1986.251.4.R787

1986General Mitochondrial Bioenergetics

Kinetics of inhibition and binding of dicyclohexylcarbodiimide to the 82,000-dalton mitochondrial K+/H+ antiporter

Martin WH, DiResta DJ, Garlid KD.

J Biol Chem. 1986 Sep 15;261(26):12300-5.

1986Water state in mitochondria, IMAC, & bioenergetics

Evidence for the existence of an inner membrane anion channel in mitochondria

Garlid KD, Beavis AD.

Biochim Biophys Acta. 1986;853(3-4):187-204. doi: 10.1016/0304-4173(87)90001-2. doi:10.1016/0304-4173(87)90001-2

1985

Ionic transport across corneal endothelium

A. Lyslo, S. Kvernes, K. Garlid, and S. K. Ratkje

A. Lyslo, S. Kvernes, K. Garlid, and S. K. Ratkje (1985) Ionic transport across corneal endothelium. Acta Ophthalmol. 63, 116-125.

1985Water state in mitochondria, IMAC, & bioenergetics

Swelling and contraction of the mitochondrial matrix. II. Quantitative application of the light scattering technique to solute transport across the inner membrane

Garlid KD, Beavis AD.

J Biol Chem. 1985 Nov 5;260(25):13434-41.

1984General Mitochondrial Bioenergetics

Identification of an 82,000-dalton protein responsible for K+/H+ antiport in rat liver mitochondria

Martin WH, Beavis AD, Garlid KD.

J Biol Chem. 1984 Feb 25;259(4):2062-5.

1983Uncoupling proteins (UCPs) & obesity

Studies on the mechanism of uncoupling by amine local anesthetics. Evidence for mitochondrial proton transport mediated by lipophilic ion pairs

Garlid KD, Nakashima RA.

J Biol Chem. 1983 Jul 10;258(13):7974-80.

1982The mitochondrial calcium cycle & calcium signaling

On the relative roles of Ca2+ and Mg2+ in regulating the endogenous K+/H+ exchanger of rat liver mitochondria

Nakashima RA, Dordick RS, Garlid KD.

J Biol Chem. 1982 Nov 10;257(21):12540-5.

1982General Mitochondrial Bioenergetics

Quinine inhibition of Na+ and K+ transport provides evidence for two cation/H+ exchangers in rat liver mitochondria

Nakashima RA, Garlid KD.

J Biol Chem. 1982 Aug 25;257(16):9252-4.

1980General Mitochondrial Bioenergetics

On the mechanism of regulation of the mitochondrial K+/H+ exchanger

Garlid KD.

J Biol Chem. 1980 Dec 10;255(23):11273-9.

1980General Mitochondrial Bioenergetics

Induction of respiration-dependent net efflux of K+ from heart mitochondria by depletion of endogenous divalent cations

Shi GY, Jung DW, Garlid KD, Brierley GP.

J Biol Chem. 1980 Nov 10;255(21):10306-11.

1980Mitochondrial potassium cycle & cardioprotection

On the mechanism of A23187-induced potassium efflux in rat liver mitochondria

Dordick RS, Brierley GP, Garlid KD.

J Biol Chem. 1980 Nov 10;255(21):10299-305.

1979

Aqueous phase structure in cells and organelles

K. D. Garlid

K. D. Garlid (1979) Aqueous phase structure in cells and organelles. In: Cell- Associated Water (W. Drost-Hansen and J. S. Clegg, eds.), Academic Press, New York, pp. 293-361.

1979General Mitochondrial Bioenergetics

Unmasking the mitochondrial K/H exchanger: tetraethylammonium-induced K+-loss

Garlid KD.

Biochem Biophys Res Commun. 1979 Apr 13;87(3):842-7. doi: 10.1016/0006-291x(79)92034-5. doi:10.1016/0006-291x(79)92034-5

1978General Mitochondrial Bioenergetics

Unmasking the mitochondrial K/H exchanger: swelling-induced K+-loss

Garlid KD.

Biochem Biophys Res Commun. 1978 Aug 29;83(4):1450-5. doi: 10.1016/0006-291x(78)91383-9. doi:10.1016/0006-291x(78)91383-9

1975Water state in mitochondria, IMAC, & bioenergetics

Non-ionic diffusion of pentobarbital across human chorion laeve

Schruefer JJ, Haburchak DR, Garlid KD, Seeds AE Jr.

Biol Neonate. 1975;27(3-4):251-8. doi: 10.1159/000240781. doi:10.1159/000240781

1973Water state in mitochondria, IMAC, & bioenergetics

Diffusion mechanisms across human placental tissue

Seeds AE, Schruefer JJ, Reinhardt JA, Garlid KD.

Gynecol Invest. 1973;4(1):31-7. doi: 10.1159/000301706. doi:10.1159/000301706

1970

The permeability of the mitochondrial inner membrane to sucrose

J. L. Gamble, Jr. and K. D. Garlid

J. L. Gamble, Jr. and K. D. Garlid (1970) The permeability of the mitochondrial inner membrane to sucrose. Biochim. Biophys. Acta 211, 223-232.

1969Water state in mitochondria, IMAC, & bioenergetics

Permeability of different layers of the human placenta to isotopic water

Lloyd SJ, Garlid KD, Reba RC, Seeds AE.

J Appl Physiol. 1969 Mar;26(3):274-6. doi: 10.1152/jappl.1969.26.3.274. doi:10.1152/jappl.1969.26.3.274

1962

Renal tubular secretion of o- acetylaminohippurate

G. H. Mudge, K. D. Garlid, and I. M. Weiner

G. H. Mudge, K. D. Garlid, and I. M. Weiner (1962) Renal tubular secretion of o- acetylaminohippurate. Am. J. Physiol. 203, 881-885.

1961General Mitochondrial Bioenergetics

Effects of tubular secretion and reabsorption on titration curves of tubular transport

WEINER IM, GARLID KD, ROMEO JA, MUDGE GH.

Am J Physiol. 1961 Feb;200:393-9. doi: 10.1152/ajplegacy.1961.200.2.393. doi:10.1152/ajplegacy.1961.200.2.393

1959

The effects of dimercaprol (BAL) on the renal excretion of mercurials

I. M. Weiner, K. D. Garlid, D. Sapir, and G. H. Mudge

I. M. Weiner, K. D. Garlid, D. Sapir, and G. H. Mudge (1959) The effects of dimercaprol (BAL) on the renal excretion of mercurials. J. Pharmacol. Exp. Ther. 127, 325-331.